2010年福建省健康人群流行性脑脊髓膜炎带菌率及抗体水平监测分析

Analysis on Carriage Rate of Neisseria Meningitidis and Antibody Level of Epidemic Cerebrospinal Meningitis in the Healthy Population,Fujian Province,2010

[目的]了解福建省2010年流行性脑脊髓膜炎(简称流脑)流行前期健康人群带菌率及抗体水平,为制定流脑防控措施提供依据。[方法]采用分层抽样方法于2010年11月在福建省安溪县、将乐县、屏南县和龙岩市4个流脑监测点对不同性别和年龄组人群采集咽拭子及血清标本,分离鉴定脑膜炎奈瑟球菌,用酶联免疫吸附法(ELISA)检测抗体,结果用SPSS 17.0软件包进行分析。[结果]检测咽拭子标本836份,未检出脑膜炎奈瑟球菌,带菌率为0.00%。检测血清标本761份,流脑抗体阳性的693份,总阳性率为91.06%。A和C群抗体阳性率分别为86.33%和85.15%;A群以7～14岁年龄组抗体阳性率最高(95.68%),<1岁年龄组最低(56.00%),差异有统计学意义(P<0.05)。C群以15～19岁年龄组抗体阳性率最高(96.08%),1～2岁年龄组最低(44.44%),差异有统计学意义(P<0.05)。4个监测点中A、C群抗体阳性率以将乐县最高(98.05%和96.75%),最低是安溪县(67.83%和67.83%),差异有统计学意义(P<0.05)。流脑A、C群抗体水平阳性率男性为85.19%和83.60%,女性为87.47%和86.68%,差异无统计学意义(P>0.05)。[结论]2010年福建省流脑流行前期健康人群带菌率较低,流行区抗体免疫水平高于非流行区;A群流脑抗体免疫水平高于C群,A、C群流脑抗体免疫水平对3岁以上健康人群有较高的免疫保护作用;应加强3岁以下低龄儿童A群或A+C疫苗接种及非流行区健康人群的疫苗接种。

[Objective]To understand the carrier status of neisseria meningitidis （Nm） and the immune level of epidemic cerebrospinal meningitis in the healthy population in Fujian province,2010, so as to provide scientific basis for the imple- mentation of preventive and cure countermeasures against epidemic cerebrospinal meningitis. [Methods]Serum and throat swab specimens of people in different gender and age groups in selected monitoring sites were collected and cultured by stratified sampling method, neisseria meningitides were isolated and verificd, serum antibody were detected by EL1SA, and then susceptibility testing was detected by E-test method. The results of data were analyzed by SPSS 17.0. [Results]Positive of Nm wasn＇t detected among 836 throat swabs;the carrier rate was 0.00 %. The Serum total positive rate of antibodies in Nm was 91. 060/oo （693/761） ,and the antibody positive rate in Nm serogroup A and C were 86.33% and 85.15% respectively. The antibody positive rate of serogroup A was higher in the 7-14 years age group （95.68%） than 〈1-year-old age group （56.00%） ,that was statistically significant （ P d0.05）. The antibody positive rate of serogroup C was higher in the 15-19 years age group （96.08%） than 1-2 years age group （44.44%） ,that was also statistically significant（ P 0.05）. The antibody positive rate in Nm serogroup A and C was higher in Jiangle county （98.05% and 96.75% ,respectively） than in Anxi county （67.83% and 67.83% ,respectively） among four monitoring points （ P〈0.05）. The level of antibody positive rate in Nm serogroup A and C was 85.19% and 83.60% respectively in males,and 87.47% and 86. 68% respectively in females,that wasn＇t statistically significant （ P〉0.05）. [Conclusion]The carrier rate is low in the healthy population before epidemic periods,Fujian province,2010, the antibody level is higher in epidemic zone than non endemic area;the antibody level of epidemic cerebrospinal meningitis in group A is higher than that of group C, the antibody level of epidemic cerebrospinal meningitis in group A and C has higher protective immune function in healthy population aged 3 and above;group A A4-C vaccination should he strengthened in the under 3 years of age or younger children and vaccination in non endemic area healthy population.