西比灵治疗癫痫的临床研究

Clinical study on the treatment of epilepsy by the drug of ibelium

目的：研究西比灵（ＩＢＬ）辅助抗痫药（ＡＥＤｓ）在抗痫方面的临床价值。方法：将６８例癫痫（ＥＰ）分为甲、乙两组。第一阶段甲组作为治疗组，乙组作为对照组。治疗组在对照组基础上加用西比灵胶囊，每日 １０ ｍｇ，每晚一次，小儿按公斤体重给药，两组均用药３个月，然后评定其疗效。第二阶段乙组作为治疗组，第４个月开始，加用西比灵，用法同上，连用３个月，作同样观察，并以该组前３个月的观察结果用自身对照；同时还与连用６个月西比灵的甲组进行比较。结果：甲组（治疗组）加用西比灵后显效率与总有效率均明显优于对照组（Ｐ＜０．０１与Ｐ＜０．０５），甲组连用６个月西比灵，疗效进一步提高。西比灵对不同类型的ＥＰ均有效，而显效率有明显差别，特殊类型ＥＰ组优于全身大发作ＥＰ组（Ｐ＜０．０１）。结论：西比灵是一种安全有效抗ＥＰ的辅助新药，尤其对特殊类型ＥＰ更有应用前景。

Objective:TO Study the clinical value of ibelium on the treatment of epilepsy. Methods:68 patients were divided into two groups, one was control group,the other was treatment group which was dealed with ibelium.Results:In treatment group,the tiny valid and total effective rate were larger than that of control group (P < 0.01 and P < 0.05).Ibelium had effect on different kind of epilepsy,but the effective rate was different in special epilepsy and grand mal (P < 0 .01 ).Conclusion: Ibelium was a safety and effective helper of antiepileptic drugs,especially in special kind of epilepsy.