摘要
[目的]研究柴胡、黄芩配伍抗肝纤维化的作用。[方法]采用饲喂高脂饲料,饮用10%乙醇及皮下注射四氯化碳(CCL4)的复合因素法建立大鼠肝纤维化模型,应用柴胡、黄芩及配伍进行干预,酶联免疫吸附法(ELISA法)检测大鼠血清中透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层黏蛋白(LN)、Ⅳ型胶原(Ⅳ-C)的变化,探讨柴胡、黄芩及柴胡、黄芩2∶1配伍对肝纤维化大鼠的影响。[结果]柴胡-黄芩2∶1配伍能降低综合因素所致肝纤维化血清中HA、PCⅢ和Ⅳ-C的浓度(P<0.05)。[结论]柴胡、黄芩及配伍具有一定抗肝纤维化作用。
[Objective] To study the effect of Bupleurum, Seutellaria and its compatibility on hepatic fibrosis in rats. [Methods] Using the method of feeding fat diet, drinking 10% alcohol and subcutaneous injecting CCIA to lead to liver fibrosis in rat and applying Bupleurum, Seutellaria and its compatibility to treat 7 days later. The serum concentration of hyaluronic acid (HA), Ⅲ procollagen (PC Ⅲ), laminin (LN) and type IV collagen (IV-C) was detected with ELISA. [Results] Bupleurum, Scutellaria and its compatibility could decrease the concentrations of HA, PC m and IV-C in rats with hepatic fibrosis and the effect was significant in Bupleurum and Scutellaria compatibility (2:1) group. [Conclusion] Bupleurum,Scutellaria and its compatibility has some certain effect against hepatic fibrosis in rats.
出处
《天津中医药》
CAS
2012年第6期576-578,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
陕西省中医药管理局项目(zy06)
陕西省教育厅项目(12JK1016)
关键词
柴胡
黄芩
配伍
肝纤维化
Bupleurum
Skullcap
compatibility
hepatic fibrosis