66例老年冠心病患者脂蛋白分析

An analysis of liporetein in 66 patients with elderly coronary heart disease

目的探讨老年冠心病（CHD）患者的脂蛋白特点。方法取健康老年组与CHD组做对照．分别做血清十项指标检测。包括TC，TG用酶法测定对DL－CapoA.B．CⅡCⅢ．E及LP(a)用免疫比浊法测定．LDL－C依据公式计算。结果健康老年组与CHD组比较．TC．TG．HDL－C．LDL－CapoA，apoB，P＜0．001；apoCⅡ，P<0.01．TG.TC分别与apoCⅡ．apoCⅢ极相关，P＜0001．HDL－C与apoCⅡ有相关性，P＜0．05，HDL－C与apeCⅢ．apoE无相关,P>0．05。结论高TG低HDL－C水平分别是冠心病危险因素，apeCⅡ与TG水平相关，但CHD组与对照组比较，apeCⅡ为P＜O．of，apeCⅢ为P＜0，OS。TG，TC与apeC11，apoCⅢ，apoE均极相关，HDL-C与apoCⅡ有相关性，p＜0．05,HDL-C与apoCⅢ，spoE无相关。故冠心病临床不必采用apoCⅡ。apoCⅢ．apoE测定，可采用TG．TC．HDL－C．apoA．apoB．LP(a)这六项指标测定．

Objective To study the characteristics of Iipids and lipoprotein in patients with elderly coronary heart disease (CHD).Methods The items of lipids and lipoprotein were determined and compared betWeen healthy elderly persons and CHD patients,including TC,TG by enzyIne assay HDL-C,apoA,apoB,apoC Ⅱ,apoC Ⅲ,apoE and LP (a) by immunoturbidimetry. LDC - C results were calculated accordi ng to the formula. Results Comparison beteen healthy elderly person and CHD patients showed that TC,TG,HDL-C, LDL-C,apoA,apoB.P<0.001;apoC Ⅱ P<0.01.TG,TC,were significantly correlated with apoC Ⅱ.apoC ⅢP<0.001;HDL-C was correlated with apoC Ⅱ P<0.05;HDL-C was not correlated to apoC Ⅲ or apoE,P>0.05.Conclusions High TG low HDL-C and high TC low HDL are risky factors in CHD patients.hevels of TG are correlated APOC Ⅱ but comparison between CHD patients and healthy persons shows apoC Ⅱ .P <0.01,apoC Ⅲ P <0.05.TG,TC are significantly correlated with apoC H .apoC Ⅲ .apoE,HDL-C are correlated with apoC Ⅱ .P< 0.05.HDL-C isn't correlated with APOC Ⅲ and APOE.So it's not necessary to determine apoC ll,apoClII and apoE in CHD patients, but to choose TG,TC,HDL-C,apoA,apoB and LP(a) for detendnation.