肺癌患者血清VEGF-D、VEGFR-2水平及临床意义

The level of serum VEGF-D,VEGFR-2 in lung cancer patients and clinical significance

目的探讨血管内皮生长因子D(VEGF-D)、血管内皮生长因子受体2(VEGFR-2)在肺癌患者血清中的水平及其临床意义。方法血清中VEGF-D和VEGFR-2浓度的测定均采用ELISA法。结果①小细胞肺癌组、非小细胞肺癌组及健康对照组血清VEGF-D及VEGFR-2浓度差异有统计学意义,由秩和检验得出P<0.05。②肺癌患者按照肿瘤分化程度、临床分期、TNM分期及胸膜侵犯分组后血清中VEGF-D及VEGFR-2浓度比较差异有统计学意义,P<0.05。结论检测血清VEGF-D及VEGFR-2水平对研究肺癌的早期诊断、临床分期、预后判断有一定的参考价值。

Objective To explore the level of serum vascular endothelial growth factor D （VEGF-D）,vascular endothelial growth factor receptor 2 （VEGFR-2） in the patients with lung cancer and its clinical significance.Methods Serum VEGF-D and VEGFR-2 concentrations were measured by ELISA.Results ①The level of serum VEGF-D and VEGFR-2 was significant difference among small cell lung cancer group,non-small cell lung cancer group and the healthy control group （P0.05）.②Lung cancer patients grouped in accordance with the degree of tumor differentiation,clinical stage,TNM staging and pleural invasion,serum VEGF-D and VEGFR-2 concentration difference was statistically significant （P0.05）.Conclusion It has a certain reference value of early diagnosis,clinical staging,prognosis to detect lung cancer serum VEGF-D and VEGFR-2 level.