准分子激光角膜原位磨镶术后角膜内皮细胞的观察

Endothelial cells evaluation after excimer laser in situ keratomileusis

活体观察准分子激光角膜原位磨镶术 (L ASIK)治疗近视后角膜内皮细胞密度和形态学的变化。方法 :对 92例 (176眼 )接受 L ASIK矫治了 - 2 .40～ - 2 5 .0 0 D的近视患者 ,分别于术前、术后用角膜内皮镜检查角膜中央区内皮细胞 ,并对资料进行分析 ,又对其中 2 9例 (5 4眼 )术前接触镜配戴者单独立组分析。结果 :L ASIK治疗前后角膜内皮细胞密度无显著性差异 (P>0 .0 5 ) ,术后内皮细胞密度与角膜切削深度无显著相关性 (r=0 .0 2 111,P>0 .0 5 ) ,随访三个月以上接触镜组术后角膜内皮细胞密度较术前平均增加 35 1.8± 137.5 / mm2 ,P<0 .0 1,差异有非常显著性。结论 :L ASIK对角膜中央区内皮细胞没有损伤 。

Objective:To evaluate corneal endothelium damages after excimer laser in situ keratomileusis.Methods:The specular biomicroscopy of the central corneal endothelium was performed on 176 eyes of 92 patients who underwent LASIK for the correction of myopia ranging between 2 40 and 25 00D.Images of the endothelium were obtained to calculate the mean cell density (MCD).The data of the 54 eyes of 29 patients who had contact lenses before surgery were expecially analysed.Results:There was no significant difference between the MCD at preoperation and afteroperation.No correlations were found between ablation depth and the MCD at afteroperation.The MCD of the patients wearing contact lenses preoperative were reduced 351 8±137 5mm 2 than that of the three months after operation,and the difference was significant (P<0 01).Conclusion:There were no damage to the central endothelial cells by LASIK.The MCD and morphological indices maybe increased by never using contact lenses.