肠易激综合征患者血胃肠激素的变化

Diversification of Gastrointestinal Hormones in the Patients Suffering from Irritable Bowel Syndrome

目的检测腹泻型和便秘型肠易激综合征 （ＩＢＳ）患者血中胃肠激素的变化，探讨胃肠激素在ＩＢＳ病理生理上的作用及意义。方法以放免法检测ＩＢＳ患者血浆中血管活性肠肽（ＶＩＰ）、 Ｐ物质（ＳＰ）、神经肽 Ｙ（ＮＰＹ）、胰高糖素（Ｇｌｕ）的含量，并以健康体检者为对照组进行比较。结果腹泻型ＩＢＳ患者血中 ＶＩＰ含量较正常对照组明显增高（Ｐ＜０．０５）， ＳＰ、 ＮＰＹ、Ｇｌｕ含量与正常对照组之间无显著差异；便秘型ＩＢＳ患者血中ＮＰＹ较正常对照组明显降低（Ｐ＜０．０５），ＶＩＰ、ＳＰ、Ｇｌｕ含量与正常对照组之间无显著差异。结论 ＩＢＳ患者血中存在着某些胃肠激素的变化，腹泻型 ＩＢＳ患者血中 ＶＩＰ含量升高可能是其临床出现腹泻症状的病理生理学基础之一；便秘型ＩＢＳ患者血中ＮＰＹ含量的降低可能是机体为对抗便秘而产生的一种保护性反应。

Objective in order to detect the changes of gastrointestinal hormones in the patients with Irritable bowel syndrome (IBS)for the diarrheal type or the constipation type. explore the role of gastrointestinal hormones in the pathophysiology of IBS. Methods compared with the healthy control group, the contents of Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), Glucagon (Glu) and substance P were detected by radioimmunoassay. Results in the patients suffering from IBS for diarrheal type, the plasma content of VIP was significantly higher than those in the control (P＜0.05), while the contents of SP, NPY, Glu showed no difference; in the constipation type, the contents of NPY were significantly lower than those in the control (P＜0.05), while the contents of VIP, SP, Gin showed no difference. Conclusions There were changes of some gastrointestinal hormones in the patients with IBS, the increase of the content of VIP in diarrhea type was probably one of the basis of pathophysiology, which appeared its clinic symptom; the decrease of contents of NPY in the constipation type was one of the protective teaction which the body was the body produced against the constipation.