儿童初发白血病血清前白蛋白测定的临床意义

Clinical significance of serum proalbumin in primary leukemia of pediatric patients before chemotherapy

目的 了解前白蛋白 (PA)作为白血病对肝浸润的意义。方法 33例患儿在治前与其中完全缓解后的 2 4例患儿 ,和 30例健康儿童对照组 ,通过免疫比浊法测定PA ,并检测其它肝功能值。结果 33例治前患儿 ,11例PA下降 (与对照组PA相比 ,t检验P <0 .0 1) ,3例白蛋白降低 ,3例谷丙转氨酶、9例谷草转氨酶升高 ,1例总胆红素升高 ,治前PA异常的例数高于肝功能其它值异常的例数。其中经治疗完全缓解后的 2 4例患儿 ,PA及肝功能其它值则均在正常范围。结论 通过PA的检测 ,发现治前白血病对肝浸润时 。

Objective To evaluate the significanace of serum proalbumin (PA) in hepatic infiltration caused by primary leukemia of pediatric patients before chemotherapy. Methods Serum PA was measured in 33 cases before chemotherapy and in 24 of them after complete remission and in 30 normal children by immunologic nephelometry, other liver function tests were performed simultaneously. Results Before chemotherapy, among the thirty three cases, 11 of them had low PA, compared with that of normal controls, P <0.01, 3 had low serum albumin, another 3 had elevated ALT, 9 had elevated AST and one had increased total bilirubin. The case number of low PA was greater than than of other abnormal liver function tests. PA and other liver functions tests in 24 cases with complete remission all recovered to normal. Conclusion PA is more sensitive than other liver function tests in hepatic infiltration of primary leukemia of children before chemotherapy. (Shanghai Med J, 2000,23∶357 358)