COPD患者急性发作期血清TNF-α和IL-8水平改变的探究

Variation and Significance of TNF-α and IL-8 in Cases with Acute COPD

目的探讨COPD患者急性发作期血清肿瘤坏死因子（TNF-α）和白细胞介素-8（IL-8）水平变化的意义。方法回顾性分析2009~2012年我院收治的80例急性发作期的COPD患者,分为对照组和实验组。对照组为非呼吸衰竭组,实验组为呼吸衰竭组。采用全自动酶免分析仪测定其血清TNF-α和IL-8水平进行比较,并检测其呼吸功能,探究其中的相关性。结果实验组TNF-α和IL-8的血清含量均高于对照组,差异显著（P〈0.05）。实验组FEV1%小于对照组,差异显著（P〈0.05）。TNF-α和IL-8水平和患者的FEV1%呈负相关,相关系数分别为-0.72和-0.65（P〈0.05）。结论合并呼吸衰竭的COPD急性加重期患者同未合并呼吸衰竭的患者相比血清TNF-α和IL-8较高,TNF-α和IL-8的升高可能加重了COPD患者的气道阻塞,TNF-α和IL-8可以协助对患者的病情和预后进行监测。

Objective To study the variation and significance of TNF-α and IL-8 in cases with acute COPD.Methods During 2009~2012,80 cases of acute COPD in our hospital were retrospectively analyzed and divided into two groups.Control group included 40 cases was respiratory non-failure.Test group included 40 cases was respiratory failure.To use automatic ELISA to measure the levels of serum TNF-α and IL-8 and detect the respiratory function to explore the correlation.Results The levels of TNF-α and IL-8 of test group were significantly higher than control group（P0.05）.FEV1% of test group was significantly lower than control group（P0.05）.The levels of TNF-α and IL-8 had a negative correlation with FEV1%.The correlation coefficients were-0.72 and-0.65（P0.05）.Conclusion The levels of serum TNF-α and IL-8 of patients with acute COPD combined with respiratory failure are significantly higher than patients with respiratory non-failure.The increase of TNF-α and IL-8 may aggravate airway obstruction of COPD patients.TNF-α and IL-8 can help to monitor the patient＇s condition and prognosis.