肝肾阴虚及气阴两虚型糖尿病肾病肾脏叶间动脉血流状态超声分析

Investigation of Objective Indexes of Chinese Medicine Typing of Diabetic Nephropathy with Doppler Frequency Spectroscopy

目的:借助彩色多普勒频谱图,对糖尿病肾病患者肾脏叶间动脉血流参数进行分析,探索该病中医分型的客观指标。方法:选择糖尿病肾病37例,将其分为气阴两虚及肝肾阴虚两组,对其双肾叶间动脉测量:收缩期峰值血流速度(VS)、舒张期末血流速度(VD)、平均血流速度(VM)、搏动指数(PI)、阻力指数(RI)。结果:肝肾阴虚、气阴两虚及正常组进行VD、PI及RI均值比较,三组间有显著差异(均P<0.05)。VD:气阴两虚组与正常组比较差异有显著性(P<0.01)。肝肾阴虚与正常组比较,差异有显著性(P<0.01)。PI及RI:PI及RI气阴两虚与正常组比较,差异有显著性(P<0.05),肝肾阴虚与正常组比较差异有显著性(P<0.05),肝肾阴虚与气阴两虚组比较差异有显著性(P<0.05)。结论:糖尿病肾病气阴两虚及阴阳两虚组PI及RI值,可以作为糖尿病肾病分型的客观指标。

Objective:To investigate the objective index of traditional Chinese medicine typing by means of analysis bilateral renal interlobar artery blood velocity in diabetic nephropathy patient using colorful Doppler frequency spectrum. Methods:Thirty-seven diabetic nephropathy (DN) patients were divided into two group deficiency of both Qi and Yin (group A) .deficiency of both Gan, Shen and Yin (group B). The normal control were 30 healthy people. Renal interlobar artery systolic blood maximal velocity (VS),end-diastolic blood velocity (VD) ,mean blood velocity (VM),pulse index (PI) and resistant index (RI) were measured in both groups. Results:The values of VD was significantly greater in group A and group B than normal controls (P < 0.05). The values of RI and PI in group A and group B were greater than normal controls (P< 0.01). Con-clusion:The values of PI and RI were significantly different between group A and B,so they could be used as the objective index of DN typing.