阿立哌唑与利培酮治疗女性精神分裂症患者的对照研究

A control study on Aripiprazole versus Risperidone in the treatment of Female Schizophrenic

目的:比较阿立哌唑与利培酮治疗女性精神分裂症的不良反应。方法:将56例女性精神分裂症患者随机分组,分别给阿立哌唑与利培酮治疗8周,采用不良反应症状量表(TESS)于治疗2、4、6、8周末评估不良反应,同时在治疗前后分别测定血清催乳素水平,并了解患者性功能的变化。结果:两组不良反应总评分无显著性差异,但阿立哌唑较少引起锥体外系反应(EPS)和性功能障碍,其血清催乳素水平明显低于利培酮组。结论:阿立哌唑疗效好,不良反应轻,是治疗女性精神分裂症患者的较好选择之一,较少引起性欲改变,有利于夫妻性关系和谐和家庭的稳定。

Objective：To compare adverse events of Aripiprazole and Risperidone in the treatment of female Schizophrenic. Methods ：56 female Schizophrenic were randomly divided into two groups for 8 weeks. One group was treated with Aripiprazole, anoth- er with Risperidone. Side effects were evaluated with treatments emergent symptom scale before and after 2,4,6,8 week~ treatment re- spectively. At the same time, the serum prolactin levels were examined, and change of sexual function were observed before and after 8 weeks. Results. There was no significant difference in the TESS score, but Aripiprazole group showed lower scores in extra - pyrami- dal symptoms, prolactin level and sexual function change. Conclusions： Aripiprazole is effective drug , with slight side effects, it is beneficial for the stability of family and the harmony of sexual relation, so it can be as better choice for the female patients with Schizo- phrenia.