摘要
目的:探讨奥氮平对抽动障碍(tic disorders)的临床疗效和安全性。方法:将62例抽动障碍患儿随机分为研究组和对照组,治疗前后应用耶鲁抽动症严重程度量表(YGTSS)和副反应量表分别评定疗效及不良反应,共治疗8周。结果:奥氮平组显好率、好转率分别为61.29%、83.87%,氟哌啶醇组显好率、好转率分别为58.06%、72.55%。治疗第2周末、第4周末及第8周末,研究组和对照组的YGTSS总分较治疗前均有显著性降低(P<0.05),研究组各阶段的YGTSS总分均显著低于对照组(P<0.05)。结论:奥氮平和氟哌啶醇对儿童抽动障碍均有较好疗效,但奥氮平的疗效和安全性更好。
Objective :To evaluate the efficacy and safety of Qlanzapine in the treatment of tic disorders in children. Methods : total o f 62 children with tic disorder were randomly divided into study group with Olanzapine and control group with Haloperidol for treatment of 8 weeks. Results: The effective rate and improvement rate in patients receiving Olanzapine were 61.29% and 83.87% , respectively, as compared with 58.06% and 77.41% in patients receiving haloperidol. In the 2nd, 4th and 8th weekend total scores o f YGTSS both in study group and control group significantly decreased ( P 〈 0.05 ) . But in every period, the total scores of YGT SS in study group were significantly lower than those in control group. The effective rates had significant differences between two groups in the 4th and 8th weekend ( P 〈 0.05 ) . Conclusions: Olanzapine is as effective as Haloperidol for childhood Tic disorder, but Olanzapine is more effective and safe.
出处
《中国民康医学》
2012年第23期2863-2863,2893,共2页
Medical Journal of Chinese People’s Health