妊娠合并外阴阴道假丝酵母菌感染对母婴结局的影响

Influence of Vulvovaginal candidiasis During Pregnancy on Maternal-infant Outcome

目的分析妊娠合并外阴阴道假丝酵母菌感染对母婴结局的影响。方法选择上海市松江区泗泾医院2011年2月-2012年1月定期产前检查的妊娠者157例作为研究对象,均有完整的产检及生产资料,其中妊娠合并外阴阴道假丝酵母菌感染者54例作为观察组,其余103例作为正常对照组,比较两组的母婴结局。结果观察组的妊娠并发症发生率为14.8%,明显高于对照组的2.9%(P<0.05);观察组的剖宫产率为37.0%,明显高于对照组的21.4%(P<0.05);观察组新生儿早产率明显高于对照组(P<0.05),但两组新生儿的阿氏评分比较差异无统计学意义(P>0.05);观察组新生儿尿布皮炎及鹅口疮发生率分别为11.1%、9.3%,均明显高于对照组的1.9%、1.0%(P均<0.05)。结论妊娠合并外阴阴道假丝酵母菌感染会增加妊娠期并发症以及新生儿感染的发生,对母婴结局有不利影响,临床上应通过产检及早发现感染,并及时采取正确的处理措施以改善母婴预后。

Objective To analyze the influence of vulvovaginal candidiasis during pregnancy on maternal-infant outcome.Methods Altogether 157 women with regular antenatal care and complete prenatal examination and delivery records were selected as the study objects in Sijing Hospital of Songjiang District from February 2011 to January 2012.54 women with vulvovaginal candidiasis were served as observation group,while 103 healthy women were served as normal control group.The maternal-infant outcomes were compared between the two groups.Results The incidence rate of pregnancy complications in observation group was 14.8% which was significantly higher than 2.9% in control group(P<0.05).The cesarean section rate of observation group was 37.0% which was significantly higher than 21.4% in control group(P<0.05).The premature birth rate of observation group was significantly higher than that of control group(P<0.05),but no statistically significant difference was found in the neonatal Apgar scores between the two groups(P>0.05).The incidence rates of neonatal diaper dermatitis and thrush in observation group were 11.1% and 9.3%,which were both significantly higher than 1.9% and 1.0% in control group(P<0.05 for both).Conclusions Vulvovaginal candidiasis during pregnancy will increase the incidence of pregnancy complications and neonatal infections,moreover,it has an adverse impact on maternal-infant outcomes.It is necessary to perform maternal prenatal examination,early detecting the infection and take the effective measures timely so as to improve maternal and child outcomes.