餐后高血糖人群中影响微量白蛋白尿的多因素分析

Multiple factors analysis about urinary albumin excretion rate

目的 :调查餐后高血糖人群中各种影响微量白蛋白尿的因素。方法 :以微量血糖筛查餐后 2小时血糖超过6 .6 7mm ol/ L参试者 739例 ,以非糖尿病人的微量白蛋白尿排泄率中位数为标准 ,分为正常和微量白蛋白尿两组。结果 :正常和微量白蛋白尿两组间比较 ,年龄、体重、 BMI、 WHR、 SBP、 DBP、 FBG、 PBG、 TCH、 TG有显著性差异 ,微量白蛋白尿组以上指标均较高 ,P值 <0 .0 5 ,而性别、身高、HR、FINS、PINS两组间无显著性差异。以 L og U AER为因变量 ,其它各指标为自变量的逐步回归方程中 ,仅空腹血糖和舒张压 2变量进入回归方程。结论 :影响微量白蛋白尿的因素众多 ,包括年龄、体重、BMI、WHR、SBP、DBP、FBG、PBG、TCH、TG等 ,其中最主要的两个因素是空腹血糖和舒张压。此结论和早期糖尿病肾病治疗的两个基本原则吻合 :(1)强化治疗 ,严格控制高血糖 ;(2 )严格控制高血压。

Objective:To investigate factors which affect urinary albumin excretion rate(UAER) in postprandial hyperglycemic subjects Method:739 participants were selected with postprandial finger tip blood sugar≥6 67mmol/L The participants were divided into two groups:normal and microalbuminuria group Microalbuminuria is defined as 5μg/min by median of nondiabetic participants albuminuria Results:Age 、weight、body mass index(BMI)、waist hip、ratio(WHR)、systolic blood pressure(SBP)、diastolic blood pressure(DBP)、fast blood sugar(FBG)、postprandial blood sugar(PBG)、plasma triglyceride(TG) and cholesterol(TCH) in microalbuminuria group were higher than that in normal albuminuria group significantly Multiple factor stepwise regression analysis was performed with logarithmly transformed UAER as dependant variable,and age、weight、BMI、WHR、SBP、DBP、FBG、PBG、TG、TCH as independent variable The results showed that only FBG and DBP entered regression equation Conclusion:there are many factors which effect UAER,including age、weight、BMI、SBP、DBP、FBG、PBG、TCH and TG,the most important factors are FBG and DBP The conclusion coincides with principles in treatment of early diabetic nepheropathy,that is:1 strict control of hyperglucosemia;2 Strict control of hypertesion