一种茶叶复合物缓解醉酒症状研究

Study on Remission of Drunk Symptoms by the Tea Complex

研究了一种茶叶复合物的解酒作用。通过观察小鼠灌胃白酒后翻正反射消失与恢复时间,急性乙醇中毒的死亡率,自发活动的变化以及小鼠血液中乙醇浓度,以评价茶叶复合物缓解醉酒症状的作用。结果显示:低、中、高剂量茶叶复合物均能延长翻正反射消失时间,缩短小鼠翻正反射恢复时间(P<0.01);降低急性乙醇中毒小鼠的死亡率;抑制乙醇致中枢兴奋引起的小鼠自主活动次数增多(P<0.01);高剂量茶叶复合物能显著降低灌胃乙醇后30、60、90、120、150min小鼠血液中的乙醇浓度(P<0.05或P<0.01),各时间点小鼠血浆乙醇质量浓度分别为(523±129)、(671±175)、(954±203)、(1012±326)、(634±139)mg/L。本研究为茶叶解酒产品的开发提供了一定的理论基础。

To study anti-inebriation effects of a kind of tea complex and its effects were evaluated by observing the time loss and the recovery time of righting reflex,the death rate induced by acute alcoholism,alcohol-induced spontaneous activity and alcohol concentration in mice plasma.The results showed low,middle and high dose of tea complex prolonged the loss time of righting reflex and shortened the recovery time of righting reflex,reduced the death rate induced by acute alcoholism,inhibited ethanol-induced spontaneous activity of mice and obviously decreased alcohol concentration in mice plasma.The alcohol concentration at 30,60,90,120,150 min after oral administration high dose of tea complex were（523±129）,（671±175）,（954±203）,（1012±326）,（634±139） mg/L respectively which showed significant differences compared with that of control group（P0.05 or P0.01）.This research would provide the groundwork for the development of tea.