定君生治疗妊娠期外阴阴道假丝酵母菌病的观察

Treatment of vulvovaginal candidiasis in pregnancy by live preparation of lactobacillus: an observation

目的探讨定君生联合两性霉素B对妊娠期外阴阴道假丝酵母菌病的临床疗效,为妊娠期的安全用药提供参考。方法选取116例妊娠期外阴阴道假丝酵母菌病患者,随机分为对照组和治疗组,对照组单纯给予两性霉素B,治疗组在对照组的基础上给予定君生,分别于治疗后10、30和60 d对患者的临床疗效和阴道分泌物情况进行评价。结果治疗后60 d治疗组总有效率显著高于对照组(94.82%vs 82.76%,P<0.05);治疗后60d治疗组复发例数明显少于对照组(12.07%vs 29.31%,P<0.05)。结论定君生联合两性霉素B对妊娠期外阴阴道假丝酵母菌病的临床疗效显著,且其治疗效果维持时间长,可较好的预防患者复发。

Objective To explore the clinical effect of live preparation of lactobacillus and amphotericin B in treatment of vulvovaginal candidiasis in pregnancy,and provide a reference for drug safety during pregnancy.Methods 116 cases of vulvovaginal candidiasis in pregnancy were divided into control group and treatment group.The patients of control group were given amphotericin B,while the treatment group were given live preparation of lactobacillus on the basis of control group medication.The effect and vaginal discharge were evaluated at 10 days,30 days and 60 days after treatment.Results After treatment for 60 days,the effective rate of treatment group was higher than in the control group（94.82% vs 82.76%,P0.05）;there was a significant difference in relapse rate（12.07% vs 29.31%,P0.05）.Conclusion Live preparation of lactobacillus and amphotericin B have long-lasting curative effect and low relapse rate in the treatment of vulvovaginal candidiasis in pregnancy.