铜绿假单胞菌群体感应系统的研究进展

The quorum sensing system of Pseudomonas aeruginosa: progress on studies

细菌的群体感应也称自身诱导,是指细菌通过产生和感应信号分子浓度的变化来监测其群体密度,协调群体行为的过程。自身诱导物随着细菌密度增高而增高,当自身诱导物达到某一阈值后,会与一些转录调节子结合,从而诱导或抑制多种基因的表达。群体感应系统内由多种信号分子和效应蛋白组成复杂的调节网络,调控包括细菌毒力因子产生与释放、生物膜形成、接合反应等,从而影响细菌的致病过程。本文主要对铜绿假单胞菌的群体感应系统及其与宿主关系、群体感应抑制剂等方面的研究进展进行综述。

Bacterial Quorum-sensing is also called autoinduce,which means the process that bacteria coordinate their group behavior through monitoring their population density via the production and detection of small signaling compounds.The level of autoinducers becomes higher with the increase of cell density.These signal molecules will bind to and activate their cognate transcriptional regulators when the level of autoinducer reaches a threshold concentration,then induce or inhibit several genes＇ expression.Three quorum sensing systems,the LasR-LasI system,RhlR-RhlI system and Pseudomonas quinolone signal system have been identified in Pseudomonas aeruginosa.Quorum-sensing system utilizes the diffusion of one or several signal molecules,embedded in a complex network of global regulation,influence bacterial group behavior.In addition,Quorum-sensing system participate the pathogenesis of Pseudomonas aeruginosa infections by regulating the production of virulence factors.With the increase of multi-drug resistant bacteria,many researchers focus on interfering with the bacterial quorum-sensing system to prevent infections by drug-resistant pathogens as a new antibiotic strategy.This review is about the research progress of Pseudomonas aeruginosa quorum-sensing system and the relationship with hosts.