腹主动脉瘤药物治疗

The medication of abdominal aortic aneurysm

腹主动脉瘤是最常见的动脉瘤,一旦破裂,病死率高达70%～95%。临床发现的腹主动脉瘤90%为小动脉瘤,外科治疗不能降低其病死率。保守治疗不仅可以减缓AAA的生长,而且可以减少病人的相关心血管事件。保守治疗包括戒烟,应用他汀类药物、抗生素、血管紧张素转换酶抑制剂、血管紧张素Ⅱ受体阻滞剂、β受体阻滞剂、维生素E、环氧化酶-2抑制剂、抗炎抗血小板药物、激素等。

Abdominal aortic aneurysm （AAA） is the most common aneurysm with a mortality rate of 70% to 95% if aneurysm rupture occurs. 90% of detected AAAs are small. Surgical management of small AAAs does not reduce mortality. The medical management of AAAs can not only limit the expansion of small AAAs but also reduce the high incidence of other cardiovascular events in AAA patients. The medical therapy for AAAs consists of smoking cessation, statins, antibiotics, angiotensin-converting enzyme inhibitors, angiotensin Ⅱreceptor blockers,β-blocker, vitamin E, cyclooxygenase-2 inhibitors, anti-platelet drugs, hormonal medications and so on.