肝病患者血清碱性谷胱苷肽S转移酶放射免疫测定及临床意义

SERUM BASIC GLUTATHIONE S-TRANSFERASE MEASUREMENTS IN PATIENTS WITH LIVER DISEASE BY RADIOIMMUNOASSAY

应用放射免疫测定法(RIA)检测277例肝病患者血清碱性谷胱苷肽S转移酶(B-GST),并以54例健康人及28例非肝病作对照,研究结果发现各型肝病血清B-GST均明显升高,提示B-GST是一项反映肝损害的敏感指标;它对急性肝炎的诊断意义与丙氨酸转氨酶(ALT)相若,但对反映慢性肝炎及轻微肝损害则较ALT敏感,且具有更好的肝胆特异性,还对肝炎预后及反映肝脏病理改变有较好的参考意义.

Serum basic glutathione S-transferase (B-GST) concentration was measured in 277 patients with liver disease, 54 healthy blood donors and 28 pat nts with non-liver disease served as the controls: The levels were found to be significantly increased in various kinds of liver disease. B-GST value in non-liver disease was within normal range. Our data suggest that serum B-GST is an ideal index of liver damage. The sensitivity of B-GST is similar to that of ALT in the diagnosis of acute viral hepatitis, while it is superior to that of ALT in the diagnosis of chronic and mild liver injuries. Besides B-GST is more specif ic than ALT in diagnosing liver disease. The changes in B-GST levls through a serial observation may be helpful to the monitoring of the prognosis of viral hepatitis. The change in serum B-GST levels is consistent with that in histoigical damage of the liver.