摘要
目的观察负压防反流技术联合白介素-2(IL-2)治疗恶性胸腔积液临床疗效及安全性。方法 196例恶性胸腔积液患者随机分为3组:A组应用负压防反流装置,将胸腔积液引流干净注入IL-2;B组应用胸腔置中心静脉导管引流胸水,无胸水流出时注入IL-2;C组应用胸腔穿刺抽液,至不能抽出胸水时注入IL-2。比较3组患者临床疗效及安全性。结果 A组136例患者胸水治疗总有效率明显高于B、C组;而1年、2年、3年无胸水生存率明显高于B、C组;所有患者耐受良好,无严重毒副反应及并发症。结论负压反流技术联合IL-2治疗恶性胸腔积液有效率及安全性高,值得临床普遍推广应用。
Objective To observe the therapeutic effects and safety of negative anti-reflux technique combined with interleukin-2 (IL-2) for malignant pleural effusion. Methods A total of 196 patients with malignant pleural effusion were randomized into three groups. Group A received thoracic drainage by negative anti-reflux device. When the effusion was drained completely, IL-2 was injected through thoracic cavity. Group B received thoracic drainage by central venous catheter, IL-2 was injected through thoracic cavity when there was no effusion flowing out. Group C received conventional pleural effusion, IL-2 was injected when the effusion couldn't be pumped. Results The total effectiveness rate in group A was significantly higher than that in groups B and C. The 1 -, 2-, and 3-year survival rate in group A were significantly higher than those in groups B and C. The patients were all well tolerated and there were no serious adverse reactions or complications. Conclusion Combination of negative anti-reflux technique and IL-2 in the treatment of malignant pleural effusion has high security and effectiveness rate, and it is worthy of clinical application.
出处
《实用临床医药杂志》
CAS
2012年第21期39-41,共3页
Journal of Clinical Medicine in Practice
基金
中高校医学期刊临床专项资金(11220212)
关键词
负压防反流技术
恶性胸腔积液
白介素-2
negative anti-reflux technique
malignant pleural effusion
interleukin-2