西吡氯铵与聚维酮碘含漱液对口腔念珠菌感染的疗效对照分析

Contrasting analysis on effect of cetylpyridinium chloride and povidone iodine on oral candidiasis

目的对比西吡氯铵与聚维酮碘含漱液对口腔念珠菌感染的疗效及安全性。方法将83例口腔念珠菌感染患者随机分为2组,治疗组(n=42)给予西吡氯铵含漱液,对照组(n=41)给予聚维酮碘含漱液。比较2组患者口腔疼痛、黏膜萎缩、红斑评分,菌落数、镜检阳性率、综合疗效及不良反应的差异。结果 2组患者各症状评分均较治疗前显著改善,但治疗组改善幅度大于对照组;2组治疗后菌落数及真菌镜检阳性率均较治疗前显著下降,但2组之间无显著差异;治疗组显效率显著高于对照组,而2组总有效率之间无显著差异。治疗组未发生明显不适反应,对照组发生1例口腔黏膜充血。结论与聚维碘酮相比较,西吡氯铵含漱液对口腔念珠菌感染患者口腔疼痛、黏膜萎缩、红斑等症状的缓解作用更强,清除真菌的作用也有一定程度的提高,且安全性高,使用方便,具有临床推广价值。

Objective To contrast the effect and safety of cetylpyridinium chloride and povi- done iodine on oral candidiasis. Methods Eightythree patients with oral candidiasis were ran- domly divided into two groups. The treatment group （ n = 42） received cetylpyridinium chloride gargarism, and the control group （n = 41 ） received povidone iodine gargarism. The symptom seorings of oral pain, atrophic mucosa and erythema, colony count, positive rate by microscopy, com- prehensive effect and adverse reactions were compared. Results The symptom scorings in the two groups after treatment obviously improved, while the improving range in the treatment group was larger than that in the control group. The colony count and positive rate by microscopy decreased obviously after treatment, but there was no significant difference between the two groups. The sig- nificantly curative rate in the treatment group was obviously higher than that in the control group, but there was no significant difference of overall response rate between the two groups. There was no apparently adverse reaction in the treatment group, while there was 1 case of oral mucosal hyperemia in the control group. Conclusion Compared with povidone iodine, cetylpyridinium chloride has better effect on oral pain, atrophic mucosa and erythema. It has certain degree of improvement in clearing fungus, high safety, convenient usage, and value for clinical popularization.