血清脂质结合唾液酸、组织多肽抗原、组织蛋白酶、卵巢癌抗原X1及CA125联合检测对卵巢上皮性癌的诊断价值

The early diagnosis of joint detection LASA,TPA,CATL,OVX1 and CA125 in patients with epithelial ovarian cancer

目的探讨血清脂质结合唾液酸(LASA)、组织多肽抗原(TPA)、组织蛋白酶(CATL)、卵巢癌抗原X1(OVX1)及CA125联检对卵巢上皮性癌(EOC)的早期诊断价值。方法选择2007年8月至2010年11月兰州大学第二医院和兰州市第一人民医院妇产科拟行手术治疗的卵巢上皮性癌患者86例及良性上皮性卵巢肿瘤患者100例、健康对照组50例,测定其LASA、TPA、CATL、OVX1血清水平。并收集相应卵巢肿瘤患者的临床资料,分析其CA125水平。结果 5项指标恶性组均明显高于良性组和健康对照组(P均<0.05)。TPA对EOC的总阳性率以及早期检测阳性率均最高,LASA和OVX1对EOC的总阳性率均低于CA125,CATL对EOC的总阳性率略高于CA125,但是对EOC早期检测阳性率均高于CA125。CA125+TPA对EOC的总阳性率以及早期检测阳性率也均为最高;余3项指标与CA125两两联合检测时对EOC早期检测阳性率均明显高于CA125单检(P均<0.05),对EOC的总阳性率均明显高于CA125单检,除CA125+OVX1与CA125单检时差异无统计学意义外,其余差异均有统计学意义(P均<0.05)。结论血清LASA、TPA、CATL及OVX1是具有潜力的EOC诊断指标,TPA和CA125联检是理想的组合方式,兼顾了对EOC的总阳性率以及早期检测阳性率,提高了对EOC的诊断率。

Objective To study the diagnostic value of combined determination of serum CA125, LASA,TpA, CATL and OVX1 in patients with early stage EOC. Methods EOC group 86,the benign epithelial ovarian tumor group 100 and healthy women group 50 of Lanzhou University Second Hospital and First Hospital of Lanzhou between 2007 and 2010 ;Serum levels of LASA, TPA, CATL and OVX1 were ascertained by enzyme-linked immunosorbent assay （ELISA） o The clinical data of the corresponding period patients with ovarian tumor were collected to analyze the serum level of CA125. Results The serum levels of CA125 ,LASA,TPA,CATL and OVX1 in EOC group were significantly higher than the benign epithelial ovarian tumor group and healthy women group （P 〈 0. 05, respectively）. In single test, the total posi- tive rate and early diagnosis rate of TPA for EOC are highest;the total positive rate of LASA and OVX1 are inferior to CA125 ,the total positive rate of CATL are slightly above CA125, but the early diagnosis rate of others are higher than CA125. In the joint test ,the total positive rate and early diagnosis rate of TPA plus CA125 for EOC are highest,the early diagnosis rate of others joint with CA125 are higher than CA125 single （P 〈 0. 05, respectively）, the total positive rate for EOC are higher than CA125 single（P 〈 0. 05, respectively）, except CA125 plus OVX1 . Conclusion The serum levels of CA125 ,LASA ,TPA, CATL and OVX1 all could be used as the important tumor markers of EOC, CA125 and TPA together is the best ,can improve the total positive rate ,early diagnosis rate and the diagnosis rate of EOC.