降钙素原对新生儿重症感染早期诊断价值的研究

The early diagnosis value of procalcitonin infection in neonatal intensive

目的探讨降钙素原(PCT)在新生儿重症感染早期诊断价值。方法对34例重症感染新生儿、25例局部感染新生儿及15例非感染新生儿在入院24 h内进行血清PCT、白细胞计数及超敏C-反应蛋白(hs-CRP)检测,比较各炎症指标的诊断灵敏度、特异性,并分析ROC曲线。结果重症感染组与局部感染组hs-CRP、PCT P50(P25,P75)比较差异有统计学意义,重症感染组PCT及hs-CRP与受试者试验曲线面积差异有统计学意义。结论血清PCT在新生儿重症感染早期诊断的灵敏度及特异性均优于白细胞计数、hs-CRP,可作为新生儿重症感染早期诊断指标。

Objective To investigate the value of procalcitonin （PCT） in early diagnosis of severe neonatal infections. Methods We divided 74 neonates into three groups, which were severe infection group （34 cases）, local infection group （25 cases） and control group （15 cases）. Serum PCT, high-sensitivity C-reaction protein （hs-CRP） and white blood cell count（WBC） were obtained in 24 hours after admission. C~）mpared with their sensitivity, and specificity and analysised receiver operating characteristic curves （ROC curve）. Results The levels of PCT and hs-CRP were signifi- cantly different between the severe infection group and the local infection group. Receiver operating characteristic curves were drawn and areas under these curves were calculated. For the assessment of infections, the sensitivity, the specificity and the accuracy of PCT was higher than hsCRP. Conclusion Compare with hsCRP and WBC, the serum PCT is better at sensitivity and specificity in early diagnosis of neonatal severe infections. PCT is an important maker in early diagnosis of neonatal severe infections.