VDR基因多态性与宁夏回汉族白癜风患者的相关性研究

Investigation on association of VDR gene polymorphism with Hui and Han ethnic vitiligo patients in NingXia

目的研究VDR基因FokI、BsmI位点与宁夏地区回汉族白癜风患者遗传易感性的关系。方法应用PCR-RFLP技术进行了宁夏回汉族白癜风患者的VDR基因FokI、BsmI位点频率分布的检测。结果 FokI位点的基因型和等位基因的分布频率在宁夏回汉族白癜风患者和对照组中均无统计学意义。BsmI位点Bb基因型的频率分布在宁夏回族白癜风组和回族健康对照组有显著性差异(P为0.033);而且Bb基因型的频率在宁夏白癜风患者组和对照组组中也有统计学意义(P值为0.036)。结论 VDR基因BsmI(rs:1544410)位点可能是宁夏地区尤其是回族人群中白癜风发病的保护因子。

Objective To evaluate the association of the polymorphism of VDR gene FokI and BsmI sites and the genetic susceptibility of Hui and Han ethnic vitiligo patients in NingXia.Methods Polymerase chain reaction sequence-restriction fragment length polymorphism（PCR-RFLP） was used to analyze the distribution of alleles and genotypes of the FokI and BsmI sites of the VDR gene among Hui and Han ethnic vitiligo patients in Ningxia.Results There was no statistically significant difference in the frequencies of VDR FokI genotypes and alleles between the vitiligo patients and healthy controls in Han and Hui nationality（P0.05）.There was statistically significant difference in the frequencies of Bb genotypes of VDR BsmI site between Hui ethnic vitiligo patients and Hui ethnic healthy controls in NingXia（P=0.033）,and also between vitiligo patients and healthy controls in NingXia.（P=0.026）.Conclusion The Bsm I（rs：1544410） site of the VDR gene was likely the protect factor in the pathogenesis of vitiligo among NingXia population,especially Hui ethnic.