急性高容量血液稀释对丙泊酚全麻诱导剂量影响的研究

Effects of acute hypervolemic hemodilution on propofol dose effect of general anesthesia induction

目的研究急性高容量血液稀释对丙泊酚诱导剂量的影响。方法选择全麻下择期行腹部手术患者28例,随机分成对照组(A组)和急性高容量血液稀释组(B组),每组14例。丙泊酚诱导剂量根据脑电双频指数(BIS)监测数值进行调整。用静脉输入泵泵入丙泊酚,当BIS值降低到40-45时,记录注入剂量,并根据患者体重计算出每公斤体重的给药剂量,同时记录患者的收缩压、舒张压、平均动脉压及中心静脉压的变化情况。结果与A组相比,B组丙泊酚每公斤体重的诱导剂量明显减少(P<0.01)。与A组相比,B组患者收缩压、舒张压、平均动脉压和中心静脉压升高。结论行急性高容量血液稀释的患者丙泊酚全麻诱导剂量明显减少。

Objective To study the effects of acute hypervolemic hemodilution on propofol induction dose effect.Methods Select undergoing elective abdominal operation under general anesthesia in 28 patients,who were randomly divided into control group（group A） and acute hypervolemic hemodilution group（group B）,14 cases in each group.Propofol induction dose based on bispectral index（BIS） monitoring numerical adjustment.By intravenous pump into the propofol,when the BIS value is reduced to 40-45,record the implantation dose,and according to the patients＇ body weight is calculated per kg body weight dosage,recorded simultaneously in patients with systolic blood pressure,diastolic blood pressure,mean arterial blood pressure and central venous pressure changes.Results Compared with A group,group B propofol induction dose per kilogram of body weight was significantly reduced（P 0.01）.Compared with A group,B group of patients with systolic blood pressure,diastolic blood pressure,mean arterial blood pressure and central venous pressure were elevated.Conclusion Acute hypervolemic hemodilution in patients during general anesthesia induction dose of propofol significantly reduced.