纳米紫杉醇联合顺铂化疗治疗晚期食管癌的效果分析

Analysis of the Clinical Effect of Nano Paclitaxel plus Cisplatin Chemotherapy in the Treatment of Advanced Esophageal Cancer

目的探讨纳米紫杉醇联合顺铂化疗治疗晚期食管癌的临床疗效及其安全性。方法选取我院2009年12月～2012年8月收治的晚期食管癌患者41例,将其随机分为观察组(20例)和对照组(21例),观察组采用纳米紫杉醇联合顺铂进行治疗,对照组采用5-氟尿嘧啶联合顺铂进行治疗,所有病例均化疗2个疗程以上,观察两组的临床治疗效果以及不良反应的发生情况。结果观察组和对照组的治疗总有效率分别为55%和38.1%,观察组的治疗有效率显著高于对照组(P<0.05),且观察组中位缓解时间和中位生存时间较对照组均显著延长(P<0.05);两组不良反应发生率的差异无统计学意义(P>0.05)。结论纳米紫杉醇联合顺铂治疗晚期食管癌的疗效优于5-氟尿嘧啶联合顺铂治疗,且不增加不良反应。

Objective To explore the clinical effect of Nano paclitaxel plus cisplatin chemotherapy in the treatment of advanced esophageal cancer. Methods 41 cases of advanced esophageal cancer hospitalized in our hospital during December 2009 and August 2012 were selected and randomly divided into the observation group （20 cases） and control group （21 cases）. Patients in the observation group were treated with Nano paclitaxel plus cisplatin, while the patients in control group were treated with 5-fluorouracil plus cisplatin. The clinical effect and incidence of adverse reactions were observed and compared after at least two treatment cycles. Results The total efficacy rate of observation group was 55 %, significantly higher than that of control group which was 38.1% （P〈0.05）. The median response duration and the median survival time of observation group were both significantly longer than those of the control group. No significant difference of the incidence rate of adverse reactions was observed between the two groups （P〉0.05）. Conclusion Treatment with Nano paclitaxel plus cisplatin was more effective for advanced esophageal cancer than 5-fluorouracil plus cisplatin, and no more adverse reactions were found.