食管癌术后吻合口瘘的保守性药物治疗研究

Conservative Drug Therapy for Esophageal Cancer Patients with Postoperative Anastomotic Fistula

目的总结食管癌患者术后吻合口瘘的诊断和个体化治疗经验,以提高治愈率。方法回顾性分析2007年1月至2011年12月于我院行食管癌根治术后吻合口瘘的患者52例,分为2组,观察组采用保守性药物治疗,对照组采用手术治疗。结果观察组所有患者治疗后均痊愈,11例出现并发症,生活质量良好;对照组患者17例出现并发症,1例死亡。结论食管癌患者出现术后口瘘时,应联合应用抗菌药物、制酸药物、全胃肠动力药物、生长抑素、生长激素等药物,并给予胃肠减压、有效的胸腔引流、充分的营养支持等综合治疗措施,从而提高食管癌术后吻合口瘘的治愈率。

Objective In order to improve the cure rate of the esophageal cancer patients with postoperative anastomotic fistula, we sununarized the experience of diagnosis and individualized treatment on the disease. Methods Retrospective analysis was carried on 52 esophageal cancer patients with postoperative anastomotic fistula from January 2007 to December 2011 in our hospital. They were divided into two groups. The observation group was treated with conservative medical therapy, and the control group was treated with surgery. Results All patients in the observation group were cured after treatment, only 11 of them had complications, but with good quality of life. While in the control group, 17 patients had complications and one patient died. Conclusion Esophageal cancer patients with postoperative fistula should take antimicrobial drags, antacid drugs, gastrointestinal motility drags, somatostatin, growth hormone and other drugs, and receive comprehensive treatment measures like gastrointestinal decompression, effective chest drainage, and adequate nutrition support, so that the cure rate of esophageal anastomotic fistula can be improved.