非对称杂化的手性膦-亚磷酰胺酯配体在不对称催化反应中的应用进展

Progress on Unsymmetrical Hybrid Chiral Phosphine-phosphoramidite Ligands and Their Application in Asymmetric Catalytic Reactions

非对称杂化的手性膦-亚磷酰胺酯配体因其合成简便、易于调控、结构稳定等优点,被广泛应用于不对称催化反应中,如:不对称氢化、不对称氢甲酰化、不对称烯丙基烷基化、不对称氢膦酰化、不对称[3+2]-环加成、不对称1,4-加成和1,4-还原反应等.综述了手性膦-亚磷酰胺酯配体的种类、合成及其在不对称催化反应中的应用.

Unsymmetrical hybrid chiral phosphine-phosphoramidite ligands have the advantages of easy accessibility, modu- larity and stability toward air and moisture, which make them highly appealing for asymmetric catalysis. These ligands have been found widespread utility in asymmetric catalysis, such as hydrogenation, hydroformylation, allylic alkylation, hydro- phosphorylation, [3 ＋2] cycloaddition, 1,4-addition and 1,4-reduction. The types, synthesis and applications of chiral phosphine-phosphoramidite ligands are reviewed.