微波技术在10-羟基喜树碱醚化反应中的应用

Application of Microwave Technique into Etherification of 10-Hydroxycamptothecin

为减少喜树碱结构在碱性条件下的内酯环开环反应,将微波技术应用于10-羟基喜树碱的醚化反应中,与常规加热条件相比,微波反应不仅极大地缩短了反应时间,同时也将反应收率从20%～30%显著地提高到50%～83%.这一研究结果对喜树碱的其他类型反应也具有可借鉴作用.

In an effort to reduce the cleavage of E lactone ring in camptothecin, microwave technique was applied in the eth- erification of lO-hydroxycamptothecin. Compared with the conventional heating condition, microwave can truncate the reac- tion time and improve the yield from 20%--30% to 50%~83% significantly. Furthermore, this reaction condition could be used for reference in other relative reactions of camptothecins.