脂肪酸结合蛋白及其生物学功能

Fatty acid-binding proteins and its biological characteristics

脂肪酸结合蛋白(fatty acid-binding protein,FABP)是胞内脂质结合蛋白超家族成员,存在于脊椎动物和无脊椎动物的细胞内,在长链脂肪酸的摄取、转运及代谢调节中发挥重要作用,并涉及生物体的其他生命过程。本文从FABP的分布、类型、结构、结合及表达特征、生物学功能,特别是近来发现的免疫调节功能等方面阐述了FABP的研究进展,为深入研究该基因家族提供参考。

Fatty acid-binding proteins（FABPs） are members of intracellular lipid binding protein superfamily.These proteins are extensively expressed in animals including invertebrates and vertebrates,and responsible for long chain fatty acid uptake,transport and metabolic regulation and also be involved in many other biological processes.This article reviews research advances in the distribution,type,structure,binding and expression features,immune regulation and the other important biological roles of FABPs.This information presented here will put insights into further studies on FABPs.