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GLIPR-2的生物学特性及与疾病的关系 被引量：1

The biological characteristics of GLIPR-2 and its relationship with diseases
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摘要 神经胶质瘤致病相关蛋白2(glioma pathogenesis-related protein 2,GLIPR-2)是CAP蛋白质超家族中的一种高尔基体膜蛋白,具有CAP保守结构域,在体内的分布具有一定的组织和细胞特异性,在免疫器官和肺脏中表达较高。GLIPR-2与细胞膜系统具有高度的亲和力,可能与十四酰基化有关。GLIPR-2在HSAB和紫外光作用下形成二聚体,且能与Caveolin-1相互作用。GLIPR-2与疾病也很相关,目前发现GLIPR-2能诱导肾脏上皮细胞发生上皮细胞间质转化(epithelial to mesenchymal transition,EMT)而参与肾脏纤维化。CAP家族的SCRIP-3和GLIPR-1与肿瘤关系密切,GLIPR-2与上述两个蛋白具有相似的保守结构域,因此GLIPR-2可能也与肿瘤有关。 GLIPR-2 is a golgi membrane protein belonging to the CAP super family which has a conserved CAP domain.GLIPR-2 is mainly expressed in immune system and lung.GLIPR-2 has a high binding activity to lipid of membrane,which may be correlated with N-myristoylation.After treatment with HSAB and ultraviolet ligh,GLIPR-2 may form dimmer and interact with Caveolin-1.GLIPR-2 can induce epithelial to mesenchymal transition（EMT） in kidney epithelial cells and promote kidney fibrosis.SCRIPR-3 and GLIPR-1,which belong to CAP super family,have close relationship with cancer.Having the same conserve domain with SCRIPR-3 and GLIPR-1,GLIPR-2 may also be involved in cancers.
作者 刘飞 黄绍光 孔维林 李涛 蒲晓允
机构地区 第三军医大学新桥医院检验科 第三军医大学西南医院心胸外科 第三军医大学新桥医院全军肿瘤研究所
出处 《生命的化学》 CAS CSCD 2012年第6期533-536,共4页 Chemistry of Life
关键词 GLIPR-2 GAPR-1 肾纤维化 EMT 肿瘤 GLIPR-2 GAPR-1 kidney fibrosis EMT cancer
分类号 R739.4 [医药卫生—肿瘤]
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参考文献12

  • 1Eberle HB et al. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid?enriched microdomains in the Golgi complex.J Cell Sci, 2002, 115: 827-838.
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同被引文献16

  • 1Zhao YY,Xu Q.Metabolomics in chronic kidney diseases[J].Clin Chim Acta,2013,CCA-13052.
  • 2Zeisberg M,Neilson EG.Mechanisms of tubulointerstitial fibrosis[J].J Am Soc Nephrol,2010,21 (11):1819-34.
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  • 4Schreiber MC,Karlo JC,Kovalick GE.A novel cDNA from Drosophila encoding a protein with similarity to mammalian cysteine-rich secretory proteins,wasp venom antigen 5,and plant group 1 pathogenesis-related proteins[J].Gene,1997,191 (2):135-141.
  • 5van Loon LC,van Kammen A.Polyacrylamide disc electrophoresis of the soluble leaf proteins from Nicotiana tabacum var." Samsun" and" Samsun NN".Ⅱ.Changes in protein constitution after infection with tobacco mosaic virus[J].Virology,1970,40(2):190-211.
  • 6Baxter RM,Crowell TP,George JA,et al.The plant pathogenesis related protein GLIPR-2 is highly expressed in fibrotic kidney and promotes epithelial to mesenchymal transition in vitro[J].Matrix Biology,2007,26(1):20-29.
  • 7Eberle HB,Serrano,et al.Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex[J].J CELL sci,2002,115 (pt4):827-838.
  • 8Eisenberg I,Barash M,Kahan T,et al.Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain[J].Gene,2002,293(1-2):141-148.
  • 9Fernández C,Szyperski T,Bruyère T,et al.NMR solution structure of the pathogenesis-related protein P14a[J].JMol Biol,1997,266 (3):576-593.
  • 10Szyperski T,Fernandez C,Mumenthaler C,et al.Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system[J].Proc Natl Acad Sci USA,1998,95 (5):2262-2266.

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生命的化学
2012年 第6期

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