慢性阻塞性肺病患者自身免疫机制

The autoimmune mechanism in infectors of chronic obstructive pulmonary disease

慢性阻塞性肺病（chronic obstructive pulmonary disease,COPD）是以不可逆性阻塞性肺气肿为特征的慢性呼吸系统疾病,是全球死亡和病死的主要原因之一,与吸烟密切相关,然而研究发现只有少部分（约15%~20%）吸烟者发展为临床的COPD,这就说明COPD患者肺部存在异常炎症反应的调节机制,自身免疫机制可能发挥着重要作用。本文主要就近年来COPD体液免疫机制、细胞免疫机制及免疫机制相关基因等方面的研究进展做一综述。

Chronic obstructive pulmonary disease（COPD） is a leading global cause of morbidity and mortality that is characterised by inexorable deterioration of small airways obstruction with emphysema,closely related to smoking.However,only a small part（about 15%~20%） of smokers develop into COPD,which indicates that the regulation mechanism of abnormal inflammatory response lies in the lungs of patients with COPD and an autoimmune mechanism may plays an important role.In this paper,we mainly reviewed the humeral and cellar immune mechanisms as well as the genes associated with them in COPD in recent years.