Ⅲ型干扰素的抗肿瘤作用

Anti-tumor effect of type Ⅲ interferon

研究发现Ⅲ型干扰素（IFN-λ）具有抗黑色素瘤、肝细胞癌、食管癌、纤维素瘤等的作用。IFN-λ不仅能抑制黑色素瘤的转移，还可引起细胞凋亡；组成性表达的IFN-λ使自然杀伤细胞活化，从而影响肝细胞癌的生长；在食管癌中，IFN-λ能诱导G-期细胞的停滞或直接导致细胞凋亡；IFN-λ入可通过诱导固有免疫和适应性免疫反应来抑制体内纤维肉瘤的生长。这些抗肿瘤机制的研究为IFN-λ运用于肿瘤临床治疗提供了新的思路。

It is reported that type m interferon （IFN-λ） has an anti-tumor effect on melanoma, hepa- tocellular carcinoma, esophageal carcinoma and fibrosarcoma in recent years. IFN-λ could not only inhibit mel- anoma metastasis, but also induce cell apoptosis ; its constitutively expression could activate natural killer ceils, affecting hepatocellular carcinoma growth; IFN-λ. could induce cells of G1 phase in esophageal carcinoma directly to stagnation or apoptosis; IFN-λ could cause native and adaptive immune response to suppress fibrosarcoma growth. Research on the anti-tumor mechanisms of IFN-λ will provide new ideas for clinical tumor therapy.