T淋巴母细胞淋巴瘤的研究进展

Research progress in T-cell lymphoblastic lymphoma

T淋巴母细胞淋巴瘤（T—LBL）是非霍奇金淋巴瘤（NHL）中的一种少见类型，好发于儿童和青年，生物学特征类似于T细胞急性淋巴细胞白血病。T-LBL病变进展较快，传统NHL样化疗方案的疗效并不理想，目前已明确应采用急性淋巴细胞白血病样方案治疗，造血干细胞移植（HSCT）可能改善LBL患者特别是难治复发患者的生存。

T-lymphoblastic lymphoma （T-LBL） is a rare form of non-Hodgkin lymphoma （NHL）, which is biologically similar to T-acute lymphoblastic leukemia （ALL）, and occurs most frequently in childhood and adolescence. T-LBL progresses fast. The treatment of LBL with conventional chemotherapy regimens for NHL has shown relatively low rates of complete remission and of disease-free survival. Now,it is reasonable to treat patients with LBL with the current ALL-type protocols, and hematopoietic stem cell transplantation may yield a more favorable overall survival （OS） in T-LBL patients, especial in relapsed or refractory LBL patients.