P-gp和ABCG2在口腔扁平苔藓、白斑及鳞癌中的表达及临床分析

The Expression of P-gp and ABCG2 in Oral Squamous Moss,White Spot and Squamous Carcinoma

目的:探讨P-gp和ABCG2在口腔扁平苔藓、白斑及口腔鳞状细胞癌中的表达及临床意义。方法:选取150例研究对象,随机分为四组:口腔扁平苔藓组30例、口腔白斑组60例(根据病理再分为轻、中、重度非典型性增生3个亚组)、观察组(口腔鳞状细胞癌组)30例、健康组30例,四组患者均行P-gp和ABCG2检测,比较组间差异。结果:口腔扁平苔藓组阴性,口腔白斑组P-gp和ABCG2阳性率均随恶性度增加而上升,轻、中、重度非典型增生的P-gp阳性率分别为15%、25%、40%,ABCG2阳性率分别为10%、20%、25%。观察组患者的口腔鳞状细胞癌组织中,P-gp表达阳性率为89%,ABCG2的表达阳性率为81%,对照组P-gp和ABCG2的表达率分别是61.5%和50%,组间比较差异有统计学意义(P<0.05)。结论:口腔白斑、口腔鳞状细胞癌患者检测P-gp、ABCG2的表达具有重要意义,可辅助临床制定化疗方案及推断患者预后。

Objective：To investigate the expression of P-gp and ABCG2 in oral lichen pianus, leukopiakia and oral squamous ceil carcinoma and its clinical significance.Method： 150 cases of the object of study, were randomly divided into four groups：oral lichen planus group 30 cases, 60 cases of oral leukoplakia group （ according to the pathological divided into light, medium, severe atypical hyperplasia 3 subgroups ）, the observation group （ oral squamous cell carcinoma in 30 cases of healthy group ）, group 30, in four groups of patients both P- gp and ABCG2 testing, comparison between groups. Result：Oral lichen planus was negative, oral leukoplakia groups P-gp and ABCG2 positive rate increases with the increase of the malignant degree, light, medium, severe atypical hyperplasia of P-gp positive rates were 15%, 25%, 40%;light, medium, severe atypical hyperplasia of ABCG2 positive rates were 10%, 20%, 25% in the observation group; research object of oral squamous cell carcinoma, P positive expression rate of gp was 89%, the expression rate of ABCG2 was 81%, the control group subjects, P- gp and ABCG expression rates were 61.5% and 50%, the difference between groups was significant （ P〈 0.05 ） .Conclusion：Oral leukoplakia, oral squamous cell carcinoma patients, detection of P glycoprotein ABCG2 expression has important sense, can assist in establishing clinical chemotherapy regimen and infer the prognosis of patients with.