术前运动干预对2型糖尿病患者骨髓采集的影响

Preoperative exercise facilitates bone marrow collection in patients with type 2 diabetes

目的探讨用干细胞治疗的2型糖尿病中患者骨髓采集阶段术前运动干预对骨髓采集的影响。方法将2008年9月至2009年9月南京军区福州总医院接受干细胞治疗的2型糖尿病患者60例随机分为对照组和研究组,各30例。对照组按外科护理常规进行。研究组于术前1 h增加运动干预,即要求患者在跑步机上慢跑,使心率达到最高心率的60﹪~85﹪。采用独立t检验和四格表卡方检验方法,比较两组骨髓采集速度、穿刺次数、骨髓细胞质量及术中疼痛情况的差异。结果研究组采集速度为（274±25）s明显优于对照组（413±83）s（t=13.139,P=0.000）;多点穿刺次数为57﹪,低于对照组的93﹪（c2=10.756,P=0.001）;Ⅱ级疼痛感为10﹪,低于对照组的40﹪（c2=7.200,P=0.007）。结论术前运动干预可缩短骨髓采集时间,减轻疼痛,保证骨髓细胞质量,是骨髓采集术前安全、可行和有效的护理干预措施。

Objective To investigate if preoperative exercise can faciliate bone marrow collection in patients with type 2 diabetes.Methods Sixty patients with type 2 diabetes were randomly divided into control group and experimental group（n = 30 for each group）.All patients received routine care.Patients in experimental group were asked to run on a running machine until their heart rate reached 65﹪-80﹪ of the maximum heart rate 1 hour before operation.The duration of bone marrow collection,times of bone puncture,volume of collected bone marrow and pain score during operation were recorded for later analysis.Results The duration of collection was significantly shorter in the experimental group than in the control group（t？=？12.652,P？=？0.000）.Experimental group also has fewer bone puncture times and lower pain scores compared with control group.（c2？=？10.61,P？=？0.001,c2？=7.200,P？= 0.007）Conclusions Preoperative exercise intervention can shorten collecting duration,relieve the patients＇ pain and increase bone marrow volume collected,which is feasible and safe.