神经保护和缺血性脑卒中治疗

The neuroprotective strategy for stroke therapy

缺血性脑卒中严重危害人类健康,迫切需要有效的药物及治疗方法。神经保护治疗脑卒中,可能是有望治疗脑卒中的策略之一。在过去的几十年间,研究者对脑缺血的神经病理及分子细胞机制已经有了较为深入的了解,发现了很多缺血后神经元中特异性的病理通路及其相关分子,并一直致力于找到能够用于脑卒中治疗的药物靶点。但是这些研究至今很少能转化为用于临床治疗的成果。本文针对近年来神经保护策略及遇到的困难,主要讨论卒中研究和治疗的转化医学研究。

The ischemic stroke causes severe damage to human health.Effective treatment of stroke is in an urgent demand. Neuroprotective strategy is one of the most promising ways for stroke therapy.In the past decades,investigators have known a lot about the mechanism of ischemic neuronal death and revealed many detrimental pathways.Numerous molecules were suggested as potential targets for stroke therapy and a great amount of compounds was developed to target these molecules and pathways.However,almost none of them have reached clinical application in stroke treatment.In this review,we will discuss the neuroprotective strategy and its possible translational studies in stroke therapy.