不同分级的脑白质疏松症患者认知功能障碍的特点

The features of cognitive impairment in patients with different rating leukoaraiosis

目的研究不同分级脑白质疏松(LA)患者各自认知功能障碍的特点。方法将80例LA患者按照头颅MRI像上白质疏松程度分为4组,用简易智能状态检查量表(MMSE)评定其整体认知功能及各个分项评分。通过统计分析,判定各组间认知功能是否存在统计学差异。结果 MMSE总分在LA各组间比较P>0.05。注意力评分,LA 4级组评分显著低于LA 1级组评分(P<0.05)。延时记忆分数评分,LA 3组评分显著低于LA 1组评分;LA 4级组评分显著低于LA 1级组和LA 2级组评分(P<0.05)。结论 LA不同分级患者整体认知功能差别不大,但在注意力及延时记忆中,LA分级越严重组越容易出现损害。

Objective To investigate the features of cognitive impairment in patients with different rating leukoaraiosis. Methods The brain magnetic resonance imaging（ MRI ） findings were obtained in 80 patients with leukoaraiosis. According to the different rating leukoaraiqsis patients were divided. Results The total score in MMSE of LA groups had no statistical difference . But LA4 group had lower scores of attention than LA1 group（P 〈 0.05 ）. LA 3 group had lower scores of delay memory than LA1 group ; LA4 group had lower scores of delay memory than LA1 group and LA2 group. （P 〈 0 . 05 ）. Conclusion Total cognition in the subgroups had not difference. The higher the LA group level as well as the more severe the cognition impaired.