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类胰岛素肽脑内作用研究进展

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摘要 胰岛素、胰岛素样生长因子I（insulin—likegrowth factor 1，IGF1）和胰岛素样生长因子Ⅱ（insulin—like growth factor2，IGF2）是胰岛素超家族中结构和功能密切相关的一组多肽，合称为类胰岛素肽（insulin—like peptides，ILPs），它们在机体外周组织中对能量代谢和组织重构的关键性调节作用已经成为人们的共识。
作者 殷一博 梁洪生 张相彤
机构地区 哈尔滨医科大学附属第一医院神经外科
出处 《脑与神经疾病杂志》 2012年第6期477-480,共4页 Journal of Brain and Nervous Diseases
基金 国家自然科学基金项目(81041082)
关键词 类胰岛素 胰岛素样生长因子Ⅱ 多肽 脑内 组织重构 能量代谢 外周组织 超家族
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献30

  • 1Bolos M, Fernandez S, Torres - Aleman I. Oral administration of a GSK3 inhibitor increases brain insulin - like growth factor I levels. J Biol Chem, 2010, 285 : 17693 - 17700.
  • 2Nishijima T, Piriz J, Duflot S, et al. Neuronal activity drives localized blood - brain - barrier transport of serum insulin - like growth factor - I into the CNS. Neuron, 2010, 67 : 834 - 846.
  • 3Sehat B, Tofigh A, Lin Y, et al. SUMOylation mediates the nuclear translocation and signaling of the IGF - 1 receptor. Sci Signal, 2010, 3 : ral0.
  • 4Marino JS, Xu Y, Hill JW. Central insulin and leptin - mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab, 2011, 22:275-285.
  • 5Morton GJ, Cummings DE, Baskin DG, et al. Central nervous system control of food intake and body weight. Nature, 2006, 443 : 289 - 295.
  • 6Trejo JL, Piriz J, Llorens- Martin MV, AM, et al. Central actions 0f liver- derived insulin - like growth factor I underlying its pro - cognitive effects. Mol Psychiatry, 2007, 12 : 1118 - 1128.
  • 7Chiu SL, Chen CM, Cline HT. Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo.Neuron, 2008, 58: 708- 719.
  • 8Sousa- Nunes R, Yee LL, Gould AP. Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature, 2011, 471 : 508 -512.
  • 9Lee CC. Huang CC, Hsu KS. Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rael signaling pathways. Neuropharmaeology, 2011,6l : 867 - 879.
  • 10Sosa L, Dupraz S, Laurino L, et al. IGF - 1 receptor is essential for the establishment of hippocampal neuronal polarity. Nat Neurosci, 2006, 9 : 993 - 995.

二级参考文献7

  • 1Ding Q,Vaynman S,Akhavan M,et al.Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function[J].Neuroscience,2006,140:823-833.
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  • 5Shi L,Linville MC,Tucker EW,et al.Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus[J].Cereb Cortex,2005,15:571-577.
  • 6Aberg ND,Johansson UE,Aberg MA,et al.Peripheral infusion of insulin-like growth factor-I increases the number of newborn oligodendrocytes in the cerebral cortex of adult hypophysectomized rats[J].Endocrinology,2007,148:3765-3772.
  • 7Sonntag WE,Lynch C,Thornton P,et al.The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing[J].J Anat,2000,197:575-585.

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脑与神经疾病杂志
2012年 第6期

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