摘要
目的研究天然藻蓝蛋白对SD大鼠的长期毒性。方法将天然藻蓝蛋白水溶液分为高、中、低3个剂量与蒸馏水对照,对80只SD大鼠连续灌胃12周,恢复4周。除观察动物一般状态外,第12、16周分别对给药末期大鼠及恢复期结束的大鼠进行连续处死,检测血常规、血生化指标,精密量取心、肝、脾、肺、肾等重要脏器,计算其脏器系数,并进行常规病理检查。结果天然藻蓝蛋白对大鼠的一般状态、血常规、血生化指标、主要脏器质量系数及组织病理均无明显影响。停药4周后上述结果未见明显异常。与空白对照组比较,未见与天然藻蓝蛋白相关的明显异常。结论大鼠长期毒性试验表明天然藻蓝蛋白口服无毒性。
Objective To investigate the chronic toxicity induced by oral administration of Phycocyanin to Sprague Dawley rats.Methods Rats were randomly divided into four groups： control group,which received the distilled water,and three treatment groups,which received oral administration of high,medium and low doses of Phycocyanin.Totally 80 SD rats were continuously administrated for 12 weeks,and then recovered for 4 weeks.Except for general factors such as bodyweight,food consumption and daily behavior,the routine biochemical blood indictors,the organ/bodyweight rate,the pathological changes of important organs such as heart,liver,spleen,lung,kidney,brain were also detected after 12 weeks and 16 weeks.The viscera coefficient was calculated,and pathological was examed routinely.Results There was no significant influence of Phycocyanin on the blood routine,serum indictors and organ/bodyweight rate of the three dose group rats.Conclusion The results of long-term toxicity experiment show that oral administration of Phycocyanin is safe.
出处
《中国医药导报》
CAS
2012年第33期15-17,21,共4页
China Medical Herald
基金
国家海洋局海洋公益性行业科研专项经费项目(项目编号:201205027)
