维持性血液透析患者颈动脉粥样硬化的相关因素分析

Correlation analysis of carotid atherosclerosis in maintenance hemodialysis patients

目的研究维持性血液透析(maintenance hemodialysis,MHD)患者颈动脉粥样硬化的可能影响因素。方法收集2008年12月～2011年12月我院收治的MHD患者59例,均行MHD治疗1年以上,根据有无颈动脉粥样硬化分为动脉硬化组和对照组,收集各组患者的临床及生化数据,采用高频B超检测其颈动脉及心脏,分析其与颈动脉粥样硬化的关系。结果 59例患者中23例有颈动脉粥样硬化(38.9%),粥样硬化组患者年龄、白细胞计数、总胆固醇(TC)高于对照组,差异有统计学意义(P<0.05或P<0.01);粥样硬化组室间隔厚度(IVSd)高于对照组,差异有统计学意义(P<0.05)。结论 MHD患者易发生颈动脉粥样硬化,年龄、白细胞计数、总胆固醇水平是主要危险因素;颈动脉粥样硬化的发生与室间隔厚度关系密切。

Objective To study potential factors of carotid atherosclerosis in MHD patients.Methods 59 cases with MHD in our hospital from December 2008 to December 2011 were collected,all the patients were treated over 1 year.All patients were divided into atherosclerosis group and control group based on carotid atherosclerosis.The clinical data and biochemical parameters were collected,carotid artery and heart were evaluated by highresolution B-mode ultrasonograph,the relationship with the carotid atherosclerosis was analyzed.Results 23 cases were found carotid atherosclerosis in all the 59 patients（38.9%）.Age,white blood cell count and levels of TC in atherosclerosis group were found higher than those in control group,the differences were all statistically significant（P 0.05 or P 0.01）;IVSd in atherosclerosis group was found higher than that in control group,the difference was statistically significant（P 0.05）.Conclusion MHD patients have higher incidence of carotid atherosclerosis.Age,white blood cell count and levels of TC are the three major risk factors.The carotid atherosclerosis is closely associated with IVSd.