奥曲肽对重症急性胰腺炎患者氧代谢及红细胞多项指标的影响研究

Study on the influence of Octreotide on the oxygen metabolism and red cell indices of patients with severe acute pancreatitis

目的探讨奥曲肽对重症急性胰腺炎患者氧代谢及红细胞多项指标的影响。方法选取2006年4月～2012年4月于我院进行治疗的52例重症急性胰腺炎患者为研究对象,将其随机分为对照组(常规治疗组)和观察组(加用奥曲肽组)每组各26例,将两组患者治疗前及治疗后2、4 d的氧代谢指标和红细胞刚性、电泳、变形及聚集指数、免疫黏附指标进行检测及比较。结果治疗后2、4 d观察组的氧代谢指标和红细胞刚性、电泳、变形及聚集指数、免疫黏附指标改善幅度均大于对照组,差异均有统计学意义(均P<0.05)。结论奥曲肽对重症急性胰腺炎患者氧代谢及红细胞多项指标的影响明显,可以肯定其在本病治疗中的效果。

Objective To study the influence of Octreotide for the oxygen metabolism and red cell indices of patients with severe acute pancreatitis.Methods 52 patients with severe acute pancreatitis in our hospital from April 2006 to April 2012 were selected as research object,and they were randomly divided into control group（routine treatment group） and observation group（Octreotide group）,with 26 cases in each group,then the oxygen metabolism and erythrocyte rigidity index,electrophoresis index,aggregation index,deformation index and immune adhesion index of two groups before and after treatment at second and fourth day were detected and compared.Results The improvement range of oxygen metabolism and erythrocyte rigidity index,electrophoresis index,aggregation index,deformation index and immune adhesion index of observation group after the treatment at second and fourth day were all bigger than those of control group,these indexes of two groups after treatment were compared,there were all significant differences（all P 0.05）.Conclusion The influence of Octreotide for the oxygen metabolism and red cell indices of patients with severe acute pancreatitis is obvious,and its effect for the disease is confirmed.