国产、进口生长抑素治疗急性胰腺炎的成本-效果分析

Cost-effectiveness analysis of domestic and import somatostatin in the treatment of acute pancreatitis

目的比较国产、进口生长抑素治疗急性胰腺炎的成本-效果比。方法将患者分为两组,A组用国产生长抑素治疗+基础治疗;B组用进口生长抑素治疗+基础治疗。应用药物经济学的成本-效果分析方法,对两组治疗急性胰腺炎的疗效及成本进行评价。结果 1个疗程结束时,国产生长抑素和进口生长抑素的疗效无显著差异(P>0.05),有效率分别为85.71%和89.47%,两组腹痛缓解时间、血淀粉酶恢复时间和血白细胞恢复时间差异不明显;A组成本显著低于B组(P<0.05),成本-效果比分别为1 066.16和2 901.98,相差1 835.82。两组的不良反应较少且无明显差异。结论应用国产生长抑素治疗急性胰腺炎价格相对低廉,成本-效果比优于进口生长抑素。

Objective To evaluate the cost-effectiveness ratio of domestic somatostatin and import somatostatin for acute pancreatitis.Methods Two therapeutic regimens for acute pancreatitis were compared by a cost-effectiveness analysis.These regimens were composed of domestic somatostatin＋basal therapy（group A）;import somatostatin＋basal therapy（group B）.Results The effective rates of the domestic somatostatin and the import somatostatin after completion of the treatment course were similar（85.71% vs 89.47%,P 0.05）;the time of abdominal pain alleviation and recovery time of serum amylase,white blood cell were not obviously different;the cost of group A was significantly lower than group B（P 0.05）,the cost-effectiveness ratios were 1 066.16 and 2 901.98 respectively.There were no significant differences between the two groups in terms of adverse reactions.Conclusion Domestic somatostatin is cheaper yet with higher cost-effective ratio as compared with the import somatostatin.