上海郊区中老年人外周血白细胞与颈动脉内中膜厚度相关性研究

Association of peripheral white blood cell count with carotid intimal-medial thickness in middle-aged and elderly Chinese of suburban area of Shanghai

目的研究上海郊区中老年人群外周血白细胞（white blood cell，WBC）计数与颈动脉内中膜厚度（carotid intimal—medial thickness，clMT）的相关性。方法对上海市嘉定区2519名40岁以上居民进行问卷调查、体格检查以及空腹采血检测血常规、血糖、血胰岛素及血脂等生化指标。结果研究对象各主要代谢指标均随着WBC计数的升高而逐渐趋向恶化。cIMT从WBC计数下四分位至上四分位分别为0．558、0．570、0．573和0．587mm（组间趋势P〈0．01）。与下四分位WBC计数相比，WBC计数在上四分位的研究对象cIMT增厚的相对风险增加了79％，分别在男性中增加了109％，在女性中增加了29％（P〉0．05）。另外，多元线性回归分析显示外周血WBC计数是cIMT增加的独立风险指标。其中，中性粒细胞和单核细胞具有显著意义。结论上海郊区中老年人正常范围内外周血WBC计数的增加与cIMT增厚显著相关，特别在男性人群中。

Objective To investigate the association between peripheral white blood cell （WBC） count and the carotid intimal-medial thickness （eIMT） in middle-aged and elderly Chinese of suburban area of Shanghai. Methods A total of 2 519 subjects aged 40 years or older from Jiading District, Shanghai were recruited to undergo questionnaire interview, anthropometric measurements, fasting blood sampling, and carotid B-mode uhrasonog- raphy. After excluding subjects with biochemical index missing, WBC count 〉 10× 10^9/L as well as those with known myocardial infarction, cerebral infarction, corouary heart disease, and those taking lipid-lowing agents, 2 239 subjects were included in this analysis. Results Increased WBC count was associated with more unfavorable metabolic risk profiles. With the increasing quartiles of WBC count, cIMT were 0. 558,0. 570,0. 573, and 0. 587mm respectively（P for trend 〈 0. 01 ）. As compared with participants in the first WBC quartile, the risks of cIMT thickening were increased by 79% , 109% in males and 29% in females （P〉 0.05 in females）. Multiple linear regression model showed that peripheral WBC count was an independent risk marker for cIMT thickening, especially for neutrophil and monocyte count. Conclusion A high-normal WBC count was significantly associated with cIMT thickening in middle-aged and elderly Chinese of suburban area of Shanghai, especially in males.