摘要
OBJECTIVE:To evaluate the efficacy and safety of treatment based on syndrome differentiation ofTraditional Chinese Medicine(TCM) for community-acquired pneumonia(CAP).METHODS:A total of 240 CAP patients were randomly divided into the following two groups:thecontrol group was treated by anti-infection plus conventional medicine treatment;and the trial group was treated by TCM plus the above-mentioned treatment given to the controls.The course of treatment was 14 days,and the patients were followed up for 7 days.RESULTS:Of the 240 patients,235 accomplished the whole process of treatment.The five patients who withdrew from the study were brought into an intent-to-treat analysis.The therapeutic effects of the trial group were superior to those of the control group(P<0.01).The trial group took less time to become clinically stable,with a higher score in the quality of life(P<0.01).There were no significant differences in mortality rate(P>0.05),white blood cell count(P>0.05),bacterial clearance rate(P>0.05),and adverse reactions between the two integrated groups.CONCLUSION:Treatment based on TCM syndrome differentiation for CAP has the advantages of resulting in less time to achieve a stable clinical condition,improvement of clinical symptoms and quality of life,and is comparatively safe.
OBJECTIVE： To evaluate the efficacy and safety of treatment based on syndrome differentiation of Tra- ditional Chinese Medicine （TCM） for community-ac- quired pneumonia （CAP）. METHODS： A total of 240 CAP patients were ran- domly divided into the following two groups： thecontrol group was treated by anti-infection plus conventional medicine treatment; and the trial group was treated by TCM plus the above-men- tioned treatment given to the controls. The course of treatment was 14 days, and the patients were fol- lowed up for 7 days. RESULTS： Of the 240 patients, 235 accomplished the whole process of treatment. The five patients who withdrew from the study were brought into an intent-to-treat analysis. The therapeutic effects of the trial group were superior to those of the con- trol group （P〈0.01）. The trial group took less time to become clinically stable, with a higher score in the quality of life （P〈0.01）. There were no significant dif- ferences in mortality rate （P〉0.05）, white blood cell count （P〉0.05）, bacterial clearance rate （P〉0.05）, and adverse reactions between the two integrated groups. CONCLUSION： Treatment based on TCM syndrome differentiation for CAP has the advantages of result- ing in less time to achieve a stable clinical condi- tion, improvement of clinical symptoms and quali- ty of life, and is comparatively safe.
基金
Supported by the National Program on Key Basic Research Project(973 Program)(Grant NO.2006CB504605)
the Program for New Century Excellent Talents at the University of Henan Province(Grant NO.006HANCET-05)
关键词
综合治疗
临床试验
辨证施治
中国医药
基础
随机
肺炎
社区
Community-acquired infections
Pneu-monia
Syndrome differentiation treatment
Ran-domized controlled trials
