芪参健骨颗粒对激素性股骨头坏死大鼠血液流变和小鼠微循环的影响

Effect of Qishen Jiangu Granule on the Hemorheological Characteristics and Microcirculation of SINFH

目的考察芪参健骨颗粒对股骨头坏死模型大鼠血液流变学及小鼠微循环的影响。方法血流变试验:SD大鼠分为正常组、模型组、低、中、高剂量给药组、阳性对照组,采用全自动血流变快测仪测量各组大鼠的血液流变值。微循环实验:ICR小鼠分为空白组,低、中、高剂量给药组,采用多普勒微循环仪考察各组小鼠微循环。结果芪参健骨颗粒能调节激素性股骨头坏死大鼠血流变,低、中剂量药物具有较好的调节血液流变学的作用;各剂量给药组均能促进小鼠耳部微循环。结论芪参健骨颗粒能明显改善激素性股骨头坏死模型的血流变和促进正常小鼠微循环,从而防治激素性股骨头坏死。

OBJECTIVE To investigate the effect of Qishen Jiangu granule on the hemorheological characteristics of the rat model with steriod-induced necrosis of femoral head（SINFH） and microcirculation of mice. METHODS Hemorheological test： SD rats were randomly divided into 6 groups： control group, model group, low-, medium-, high-dose group, and the positive control group, respectively. The hemorheological values of rats from each group were measured by automatic hemorheological rapid detector. Microcirculation experiment： ICR mice were divided into 5 groups namely control group, model group, and low-, medium-, high-dose group. Laser Doppler perfusion flowmeter was adopted to detecting the microcirculation of the mice from each group. RESULTS Qishen Jiangu granule could regulate the hemorheological change on the rats with SINFH, low- and medium-dose group indicated a better drug effect on all hemorheological indexes; and the drug promoted mieroeirculation of mice from each group, especially the blood flow rate in the ears of mice. CONCLUSION Qishen Jiangu granule can obviously improve the hemoheological characteristics and microcirculatory disturbance on animal model with SINFH, so as to prevent it.