不同方案治疗丙型肝炎病毒和人类免疫缺陷病毒合并感染患者对血细胞影响的比较

Comparision of the Different Therapeutic Impact on Blood Corpuscle in Hepatitis C Virus and Human Immunodeficiency Virus Co-infected Patients

目的探讨以蛋白酶抑制剂(PIs)或非核苷类反转录酶抑制剂(NNRTIs)为主方案治疗丙型肝炎病毒(HCV)/人类免疫缺陷病毒(HIV)合并感染的患者,比较其对血细胞的影响。方法采用随机、开放、对照方法收集初次就诊的273例HCV/HIV合并感染患者为研究对象。分别用PIs(PIs组)或NNRTIs(NNRTIs组)为主的方案治疗。比较治疗前、后血红蛋白(Hb)、白细胞(WBC)、红血胞(RBC)、血小板(PLT)等指标。结果治疗后PIs组和NNRTIs组Hb、WBC、PLT、RBC均有不同程度的上升,但是NNRTIs组比PIs组上升明显,Hb分别为137.0±24.5g/L和133.0±14.7g/L,WBC分别为(5.810±1.981)×109/L和(4.440±1.244)×109/L,PLT分别为(206.0±66.7)×109/L和(135.0±42.4)×109/L,两组比较差异有统计学意义(P<0.01)。结论 PIs或NNRTIs为主治疗HCV/HIV合并感染的患者对血细胞没有影响。

Objective To explore and compare the treatment response of the PIs or NNRTIs - based therapeutic impact on blood corpuscle in HIV/HCV co - infected patients. Methods A randomized, open and control approach was performed to enroll the 273 cases of HIV / HCV co - infected patients on their initial visits and to choose PIs （ PIs group） or NNRTIs （ NNRTIs Group） based therapy treat- ment for one year. Laboratory results of hemoglobin（Hb） count, white blood cell （WBC）, red blood Cell （RBC） and platelet （Pit） were coueeted before and after the treatment. Results The hemoglobin count in Pls group were significantly higher than that in NNRTIs group （ 137.0±24.5g/L and 133.0±14.7g/L, P 〈 0. 000） , and the difference was statistically significant （ P 〈 0.01 ）. At the end of treat- ment, WBC, RBC and Plt levels in NNRTIs group was significantly higher than those in PIs. In NNRTIs and PIs group respectively, WBC were （5. 810 ± 1. 981 ）×109/L and （4. 440 ± 1. 244）×109/L, Plt were （206.0 ± 66.7 ）×109/L and （ 135.0 ± 42.4 ）×109/L. The difference between the two groups was statistically significant （P 〈 0.01 ）. Conclusion The treatment response of NNRTIs based therapy in HIV/HCV co - infected patients can increase the degree of HCV, metabolic disease progression. There is no therapeutic impact on blood corpuscle in patients wtih HCV/HIV co - infection after PIs or NNRTIs - based regimen.