速度向量成像检测糖尿病早期大鼠左心室收缩功能异常的价值

Value of Velocity Vector Imaging in the Detection of the Left Ventricular Systolic Dysfunction in Early Diabetic Rats

目的探讨应用速度向量成像(VVI)技术检测糖尿病早期大鼠左心室收缩功能改变的应用价值。方法 12只雄性SD大鼠腹腔注射链脲佐菌素建立糖尿病模型,对照组为12只匹配的雄性SD大鼠。模型建成5周后,先行常规心脏超声检查,继而采集乳头肌水平左室短轴观二维灰阶动态图像,图像导入Siemens Sygno US Workplace3.01软件进行脱机VVI分析,检测两组大鼠左室壁6个节段(前壁AW、侧壁LW、后壁PW、下壁IW、后间隔PS、前间隔AS)的峰值收缩速度(Vs)、径向应变(SRs)、径向应变率(SRRs)、切向应变(SCs)、切向应变率(SRCs)及各项参数的6个节段平均值。结果两组大鼠常规心脏超声各项指标的测值均无统计学差异。与对照组比较,DM组左室壁6个节段的Vs、SRs、SRRs、SCs、SRCs及平均值均较正常组减低,其中下壁的SCs、下壁及前间隔的SRCs两组测值差异具有统计学意义(P<0.05)。结论糖尿病大鼠早期即可发生收缩功能损害,VVI技术可较早检出这种变化,具有重要应用价值。

Objective To investigate the left ventricular systolic dysfunction in early diabetic rats with velocity vector imaging （VVI）. Methods The diabetes mellitus（DM） group comprised 12 male diabetic rats which were induced with streptozotoein. The control group comprised 12 normal male rats with matching of DM group. All rats underwent conventional echocardiography and VVI exam 5 weeks after diabetic model established. Two - dimensional eehocardiographic cine loops were obtained from the left ventricular short - axis views at the papillary muscle level and were analysised with Siemens Sygno US Workplace 3.01 software. The peak systolic radial velocity （Vs）, radial strain （SRs）, radial strain rate （SRRs）, circumferential strain （SCs）, circumferential strain rate （SRCs） and the average of the every parameter in left ventrieular six segments at the papillary muscle level were compared between the 2 groups. Results There was no statistical difference in every conventional echoeardiographic parameter between the 2 groups. Compared with the control group, the Vs, SRs, SRRs, SCs, SRCs and the average of the every parameter in the DM group reduced, and only the SCs of IW, SRCs of IW and AS in the DM group were significantly lower （P 〈 0.05 - 0. 01 ）. Conclusion Velocity vector imaging can be used to detect the left ven- tricular systolic dysfunction in early diabetic rats and become an important tool in diagnosis of the diabetic cardiomyopathy.