清热祛浊胶囊对2型糖尿病合并代谢综合征患者胰岛素抵抗的影响

Effect of Qingrequzhuo Capsule on Insulin Resistance with Diabetes Matabolic Type 2 Combined Metabolic Syndrome

目的观察清热祛浊胶囊对2型糖尿病合并代谢综合征患者胰岛素抵抗的影响。方法 2型糖尿病合并代谢综合征患者80例,在原治疗基础上加服盐酸吡格列酮30mg,1次/天。随机分为对照组和治疗组。对照组30例,仅加服盐酸吡格列酮片;治疗组50例,同时加服清热祛浊胶囊。3个月后观察指标变化。结果治疗后治疗组患者空腹血糖、餐后血糖、糖化血红蛋白、甘油三酯、血压、胰岛素抵抗指数明显下降,高密度脂蛋白胆固醇明显升高,且其下降或升高均优于对照组治疗后,具有统计学差异(P<0.05)。结论自拟方清热祛浊胶囊可以改善2型糖尿病合并代谢综合征患者的高血糖、血脂异常、高血压等多种心血管危险因子,可改善胰岛素抵抗。

Objective To observe the effect of Qingrequzhuo capsule on insulin resistance with diabetes matabolie type 2 combined metabolic syndrome. Methods Based on the original treatment, 80 patients of type 2 diabetes combined metabolic syndrome took 30mg more Pioglitazone 1 time a day. All patients were randomly allocated into the treatment and the control groups. The control group （ n = 30） took Pioglitazone only. The treatment group （n = 50） took more Qingrequzhuo capsule. We observed the change of indicators after 3 months. Results In the treatment group,the FPG,2hPG,HbA1c,TG,HDL,SBP,HOMA -IR had decreased and HDL-C had increased apparently. The results of treatment group were better than the control group （ P 〈 0.05）. Conclusion Qingrequzhuo capsule can improve heart diseases risk factors of type 2 diabetes combined metabolic syndrome patients, such as hypertension, hyperglycemia, hyperlipi- demia, and so on. It also can reduce insulin resistance.