组织蛋白酶D在涎腺腺样囊性癌表达的研究

The expression of cathepsin-D in salivary adenoid cystic carcinoma

目的 探讨组织蛋白酶D(cathepsin D ,Cath D)与涎腺腺样囊性癌 (salivaryadenoidcysticcarcinoma ,SACC)预后的关系。方法 采用免疫组织化学链亲和素法分析 5 2例SACC的Cath D表达 ,并统计学分析Cath D与SACC病理学分型、临床分期、局部复发、远处转移和患者生存率的关系。结果 Cath D表达与SACC病理学分型、局部复发和患者生存率无明显相关 (P >0 0 5 ) ,而与临床分期和远处转移呈正相关关系 (P <0 0 5 )。结论 Cath D能通过溶解基底膜、细胞外间质和结缔组织 ,从而促进SACC的远处转移 ;Cath D可作为预后指标来预测SACC的远处转移 。

Objective To investigate the relationship between Cathepsin D(Cath D) and the prognosis of patients with salivary adenoid cystic carcinoma (SACC) Methods The immunoactivity of Cath D of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin Biotin method) The relationship between Cath D and the histological type, clinical stage, local recurrence, distant metastasis of the tumor and survival rate of the patients with SACC were analysed Results Statistical analysis showed that the expression levels of Cath D were correlated positively with distant metastasis potential and clinical stage ( P <0 05), and had no significant relation with histological type, local recurrence and survival rate ( P >0 05) Conclusions Cath D can facilitate invasiveness and distant metastasis of SACC; evaluation of Cath D can act as a predictor of distant metastasis of SACC and direct the clinical treatment